Emilio Hirsch Selected Research

Phosphatidylinositols (Phosphatidylinositol)

1/2022	Phosphoinositide Conversion Inactivates R-RAS and Drives Metastases in Breast Cancer.
3/2021	Roles of phosphatidyl inositol 3 kinase gamma (PI3Kγ) in respiratory diseases.
1/2020	PI(3,4)P2 Signaling in Cancer and Metabolism.
11/2019	Downregulation of class II phosphoinositide 3-kinase PI3K-C2β delays cell division and potentiates the effect of docetaxel on cancer cell growth.
1/2018	Phosphoinositide 3-Kinase Gamma Inhibition Protects From Anthracycline Cardiotoxicity and Reduces Tumor Growth.
1/2017	Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs.
10/2016	Phosphoinositide 3-Kinase γ Restrains Neurotoxic Effects of Microglia After Focal Brain Ischemia.
4/2016	Phosphoinositide 3-Kinase-C2α Regulates Polycystin-2 Ciliary Entry and Protects against Kidney Cyst Formation.
11/2015	Phosphoinositide 3-kinase gamma controls inflammation-induced myocardial depression via sequential cAMP and iNOS signalling.
12/2014	Phosphoinositide 3-kinase γ affects LPS-induced disturbance of blood-brain barrier via lipid kinase-independent control of cAMP in microglial cells.

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Emilio Hirsch Research Topics

Disease

42	Inflammation (Inflammations) 01/2022 - 03/2002
32	Neoplasms (Cancer) 01/2022 - 09/2005
19	Heart Failure 01/2021 - 01/2003
11	Hypertrophy 01/2020 - 06/2006
8	Cardiotoxicity 01/2021 - 07/2016
6	Fibrosis (Cirrhosis) 07/2021 - 12/2002
6	Cardiovascular Diseases (Cardiovascular Disease) 01/2020 - 09/2005
5	Pancreatic Neoplasms (Pancreatic Cancer) 05/2022 - 01/2016
5	Asthma (Bronchial Asthma) 01/2022 - 03/2009
5	Infections 01/2021 - 08/2005
4	Neoplasm Metastasis (Metastasis) 01/2022 - 07/2015
4	Pneumonia (Pneumonitis) 01/2017 - 04/2005
4	Atherosclerosis 08/2014 - 03/2008
4	Hypersensitivity (Allergy) 10/2013 - 03/2002
3	Pancreatitis 01/2022 - 12/2004
3	Respiratory Tract Diseases (Respiratory Tract Disease) 01/2022 - 03/2021
3	Adenocarcinoma 01/2022 - 01/2016
3	Breast Neoplasms (Breast Cancer) 01/2022 - 01/2015
3	Hemolysis 01/2017 - 12/2002
3	Liver Cirrhosis (Hepatic Cirrhosis) 01/2016 - 12/2002
3	Sepsis (Septicemia) 11/2015 - 09/2010
3	Insulin Resistance 06/2015 - 07/2009
3	Hypertension (High Blood Pressure) 11/2014 - 04/2005
3	Infarction (Infarctions) 03/2013 - 03/2010
3	Myocardial Infarction 01/2012 - 03/2010
2	Cystic Fibrosis (Mucoviscidosis) 01/2022 - 03/2021
2	Cachexia 01/2022 - 01/2018
2	Lung Diseases (Lung Disease) 03/2021 - 01/2015
2	Erectile Dysfunction 11/2019 - 12/2017
2	Carcinogenesis 01/2019 - 07/2015
2	Hematologic Neoplasms (Hematological Malignancy) 01/2018 - 07/2016
2	Chronic Obstructive Pulmonary Disease (COPD) 01/2017 - 03/2015
2	Eosinophilia 01/2016 - 01/2016
2	Sickle Cell Anemia (Hemoglobin S Disease) 07/2015 - 03/2013
2	Hyperlipidemias (Hyperlipidemia) 06/2015 - 02/2013
2	Pain (Aches) 07/2014 - 01/2012
2	Anaphylaxis (Anaphylactic Shock) 10/2013 - 03/2002
2	Thrombosis (Thrombus) 03/2013 - 01/2012
2	Leukemia 04/2012 - 02/2007
2	Lymphoma (Lymphomas) 04/2012 - 12/2005
2	Ventilator-Induced Lung Injury 11/2010 - 01/2006
2	Edema (Dropsy) 11/2010 - 03/2002
2	Reperfusion Injury 02/2010 - 04/2005
2	Diabetes Mellitus 07/2009 - 02/2006

Drug/Important Bio-Agent (IBA)

37	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2022 - 12/2004
21	Protein Isoforms (Isoforms)IBA 12/2021 - 04/2005
17	Phosphotransferases (Kinase)IBA 08/2021 - 03/2009
14	Proteins (Proteins, Gene)FDA Link 01/2022 - 12/2002
11	LipidsIBA 05/2022 - 03/2009
11	EnzymesIBA 01/2020 - 12/2004
9	Pharmaceutical PreparationsIBA 11/2019 - 09/2005
6	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 02/2013 - 04/2005
5	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 01/2022 - 11/2012
5	AnthracyclinesIBA 01/2021 - 07/2016
5	Adrenergic Agents (Adrenergic Drugs)IBA 01/2021 - 10/2012
5	CytokinesIBA 01/2018 - 01/2006
5	IntegrinsIBA 01/2013 - 01/2003
4	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 01/2022 - 10/2012
4	IronIBA 01/2022 - 04/2005
4	Biological ProductsIBA 01/2021 - 09/2011
4	5- quinoxalin- 6- ylmethylenethiazolidine- 2,4- dioneIBA 01/2018 - 03/2008
4	AntioxidantsIBA 01/2017 - 03/2013
4	Reactive Oxygen Species (Oxygen Radicals)IBA 07/2016 - 04/2005
3	Peptides (Polypeptides)IBA 01/2022 - 04/2005
3	Antineoplastic Agents (Antineoplastics)IBA 01/2021 - 01/2018
3	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2019 - 07/2016
3	ChemokinesIBA 01/2018 - 04/2005
3	Therapeutic UsesIBA 01/2017 - 03/2013
3	OvalbuminIBA 01/2016 - 03/2009
3	Immunoglobulin E (IgE)IBA 01/2016 - 10/2007
3	Angiotensin IIIBA 07/2015 - 04/2005
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 03/2015 - 02/2009
3	Chemotactic FactorsIBA 05/2014 - 06/2011
2	phosphoinositide-3,4-bisphosphateIBA 01/2022 - 01/2020
2	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 01/2022 - 10/2012
2	Adenosine (Adenocard)FDA LinkGeneric 01/2022 - 03/2002
2	Dinoprostone (PGE2)FDA Link 01/2021 - 01/2020
2	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 12/2019
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2020 - 11/2010
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2020 - 07/2015
2	CalciumIBA 01/2020 - 10/2012
2	NitritesIBA 11/2019 - 12/2017
2	CL27cIBA 12/2018 - 01/2018
2	Interleukin-12 (IL 12)IBA 01/2018 - 06/2010
2	Heme (Haem)IBA 01/2017 - 03/2013
2	GranulinsIBA 01/2016 - 01/2016
2	NADP (NADPH)IBA 07/2015 - 03/2013
2	Oxidoreductases (Dehydrogenase)IBA 07/2015 - 03/2013
2	Matrix Metalloproteinases (MMPs)IBA 12/2014 - 11/2010
2	Glucose (Dextrose)FDA LinkGeneric 11/2014 - 02/2006
2	Interleukin-6 (Interleukin 6)IBA 05/2014 - 02/2007
2	NADPH Oxidases (NAD(P)H oxidase)IBA 03/2013 - 02/2006
2	Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA 01/2013 - 06/2011
2	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 06/2011 - 03/2004
2	HemopexinIBA 04/2011 - 12/2002
2	Interleukin-4 (Interleukin 4)IBA 10/2010 - 02/2007
2	Anaplastic Lymphoma KinaseIBA 11/2008 - 12/2005

Therapy/Procedure

18	Therapeutics 01/2022 - 02/2009
3	Drug Therapy (Chemotherapy) 01/2021 - 01/2012
2	Ligation 04/2011 - 09/2010